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Managing the Side Effects of Lisdexamfetamine

  • Writer: Dr Iqbal A Mohiuddin
    Dr Iqbal A Mohiuddin
  • Aug 18
  • 4 min read

Lisdexamfetamine (Elvanse) is a medication commonly prescribed for attention deficit hyperactivity disorder (ADHD) and sometimes for binge eating disorder. It is a stimulant that helps improve focus, attention, and impulse control. However, like many medications, it can cause side effects that may affect daily life. Understanding how to manage these effects is crucial for anyone taking Lisdexamfetamine to ensure the best possible outcome.


Understanding Lisdexamfetamine Effects on the Body


Lisdexamfetamine works by increasing the levels of certain chemicals in the brain, such as dopamine and noradrenaline and serotonin to a lesser degree. These chemicals play a key role in attention and behaviour regulation. The effects of Lisdexamfetamine can be both positive and challenging.


Some common effects include:


  • Increased alertness and concentration

  • Reduced impulsivity

  • Elevated heart rate and blood pressure

  • Decreased appetite

  • Difficulty sleeping


These effects vary from person to person and depend on the dosage and individual sensitivity. It is important to monitor how your body responds to the medication and communicate any concerns with your ADHD specialist.


Close-up view of a medication bottle with pills on a wooden table
Lisdexamfetamine capsules can be very effective for treating ADHD but they may cause side effects.

Recognising and Managing Common Side Effects


While lisdexamfetamine can be very effective, it may cause side effects that require attention. Some of the most common side effects include:


  • Loss of appetite: This can lead to weight loss or nutritional deficiencies if not managed properly.

  • Insomnia: Difficulty falling or staying asleep is common, especially if the medication is taken late in the day.

  • Dry mouth: This can cause discomfort and increase the risk of dental problems.

  • Increased heart rate and blood pressure: Some people may experience palpitations or a feeling of a racing heart.

  • Mood changes: Anxiety, irritability, depression or mood swings can occur.


Practical Tips to Manage Side Effects


  1. Schedule medication early: Taking lisdexamfetamine in the morning can help reduce insomnia.

  2. Maintain a balanced diet and monitor your weight: Take lisdexamfetamine with your breakfast. Eat small, frequent meals and include protein-rich snacks to combat appetite loss.

  3. Stay hydrated: Drinking plenty of water can help with dry mouth and overall well-being.

  4. Monitor your heart rate and blood pressure: Keep track of any unusual heart symptoms and report them to your ADHD specialist.

  5. Practice good sleep hygiene: Establish a relaxing bedtime routine and avoid screens before sleep.


If side effects persist or worsen, it is important to consult your ADHD specialist. They may adjust the dosage or suggest alternative treatments.


Eye-level view of a glass of water and healthy snacks on a kitchen counter
Keep healthy snacks and water on hand to help manage medication side effects.

What Does Lisdexamfetamine Do to Someone with ADHD?


For individuals with ADHD, lisdexamfetamine helps by improving brain function related to attention and impulse control. It enhances the release of neurotransmitters that are often deficient or imbalanced in people with ADHD. This leads to:


  • Better focus on tasks

  • Reduced hyperactivity

  • Improved ability to organise and complete activities

  • Enhanced emotional regulation


The medication does not cure ADHD but helps manage symptoms effectively. It is often part of a comprehensive treatment plan that includes behavioural therapy and lifestyle changes.


Understanding how lisdexamfetamine works can help users set realistic expectations and recognise the importance of adherence to prescribed doses.


High angle view of a person writing notes with a laptop and medication on the desk
Taking Lisdexamfetamine can help with ADHD management at work and home.

When to Seek Medical Advice


While many side effects are manageable, some require immediate medical attention. Contact your ADHD specialist if you experience:


  • Chest pain or severe palpitations

  • Shortness of breath

  • Severe mood changes or suicidal thoughts

  • Uncontrolled high blood pressure

  • Allergic reactions such as rash, swelling, or difficulty breathing


Regular check-ups are essential to monitor the effects of lisdexamfetamine and adjust treatment as needed. Keeping a symptom diary can help track any changes and provide useful information for your doctor.


Click the link for more detailed information on Lisdexamfetamine side effects.


Supporting a Healthy Lifestyle While on Lisdexamfetamine


Managing the side effects of Lisdexamfetamine is not only about medication adjustments but also about adopting a healthy lifestyle. Here are some actionable recommendations:


  • Exercise regularly: Physical activity can improve mood, appetite, and sleep quality.

  • Maintain a consistent routine: Regular sleep and meal times help stabilise the body's response to medication.

  • Limit caffeine and alcohol: These can worsen side effects like insomnia and anxiety.

  • Practice stress management: Techniques such as mindfulness, deep breathing, meditation, or yoga can support emotional balance.

  • Stay connected: Support from family, friends, or support groups can provide encouragement and practical advice.


By combining medication with healthy habits, individuals can optimise their treatment outcomes and reduce the impact of side effects.


Managing the effects of Lisdexamfetamine requires awareness, communication, and proactive care. With the right strategies, it is possible to benefit from the medication while minimising discomfort and risks. Always work closely with your ADHD specialist to tailor your treatment plan to your needs.


Contact IamPsychiatry to book a private mental health assessment for ADHD titration of medication.


 
 
 

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